PrEP can help reduce your risk of contracting HIV through sexual contact or injection drug use. PrEP may be taken as a daily pill or administered as a bimonthly injection.
Approximately 1.2 million U.S. people ages 13 years and older have HIV. Of this group, about 13% are not aware that they have it.
PrEP can help reduce the risk of transmission between serodiscordant (mixed-status) partners. If you don’t have HIV but are at an increased risk of infection, talk with a healthcare professional about whether PrEP is right for you.
Pills used for PrEP belong to a class of antiviral medications called nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs).
NRTIs block the reverse transcriptase enzyme HIV uses to convert its RNA into DNA (reverse transcription). This stops the virus from multiplying in your body.
Injections for PrEP are an antiretroviral called integrase strand inhibitors (INSTIs).
INSTIs block the enzyme integrase, another protein HIV uses for reverse transcription. Like NRTIs, INSTIs prevent the virus from replicating in the body.
Before starting PrEP, and at least once every 2 to 3 months while you’re taking the medication, you need to be tested for HIV and have a negative test result.
If you’ve been exposed to HIV or have symptoms of an acute infection, you need to wait to make sure you test negative before restarting PrEP.
PrEP cannot effectively treat HIV on its own, and drug resistance may develop if PrEP is taken during an active HIV infection.
There are three approved PrEP medications.
Truvada
Truvada is a tablet taken once daily. It contains the active ingredients emtricitabine and tenofovir disoproxil fumarate. It’s available in both brand-name and generic forms.
Truvada has multiple strengths, and the dosage can vary from person to person. It can help reduce the risk of HIV infection through sexual contact or injection drug use.
It can be used by adults and adolescents who weigh at least 35 kilograms (around 77 pounds). Truvada is approved for people with male or female anatomy.
Descovy
Descovy is also a tablet that’s taken once daily. It contains the ingredients emtricitabine and tenofovir alafenamide. It’s only available as a brand-name medication.
Descovy comes in multiple strengths, and the dosage can vary from person to person. It can help reduce the risk of HIV infection through sexual contact.
It can be used by adults and adolescents who weigh at least 35 kilograms (77 pounds). Descovy is only approved for people with male anatomy.
Apretude
The Food and Drug Administration (FDA) approved the injectable medication Apretude at the end of 2021. It contains the ingredient cabotegravir and is only available as a brand-name drug.
For the first 2 months, Apretude must be injected by a healthcare professional once a month. After the first two doses, it must be injected once every 2 months to be effective.
Apretude can only be used to reduce the risk of HIV infection through sexual contact. It can be used by adults and adolescents who weigh at least 35 kilograms (77 pounds). It’s approved for people with male or female anatomy.
You may benefit from PrEP therapy if you:
- have a sexual partner who’s at risk of HIV or is HIV-positive
- do not know a partner’s HIV status
- have multiple sexual partners
- have sex without condoms or other barrier methods
- use intravenous drugs
You may not be eligible for PrEP if you:
- have had an allergic reaction to the medication’s ingredients
- have severe liver or kidney problems
- have hepatitis
If you think you may have a higher chance of developing HIV, it’s important to discuss this and the steps you can take for protection from HIV with a trained healthcare professional.
If you don’t have health insurance, you may be able to access free or lower cost PrEP, HIV testing, and other preventive services at your local health department or community clinic.
PrEP is highly effective at preventing HIV when it’s used as directed by a healthcare professional.
According to the Centers for Disease Control and Prevention (CDC)Trusted Source, PrEP pills and injections can decrease your risk of contracting HIV through sexual contact by around 99%. PrEP pills can decrease the risk of contracting HIV by around 74% in people who inject drugs.
It’s important to remember that PrEP pills aren’t effective right away. You need to take them daily for:
- at least 7 days for maximum protection during receptive anal sex
- at least 21 days for maximum protection during receptive vaginal sex
- at least 21 days for maximum protection during injection drug use
It’s unclear how long PrEP injections take to reach maximum protection.
Common side effects include:
- diarrhea
- fatigue (tiredness)
- headache
- nausea
Rare but serious side effects include:
- rash (allergic reaction)
- liver and kidney problems
- worsening hepatitis B
- lactic acidosis (too much lactic acid in the blood)
These are not all of the possible side effects of Truvada, Descovy, and Apretude.
Ask a healthcare professional or pharmacist for more information about these medications, including interactions with other prescribed or over-the-counter medications you take.
If you experience an allergic reaction or other serious side effects from PrEP medications, call 911 or local emergency services, or go to an emergency medical center right away.
